When and how to use longacting injectable antipsychotics. Fluphenazine decanoate injection is not intended for use in children under 12 years of age. Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Prolixin decanoate fluphenazine decanoate is longacting medicine for stabilizing your mood that must be given by a trained healthcare professional. Fluphenazine decanoate, a human prescription drug labeled by westward pharmaceuticals corp. Abilify maintena is a longacting aripiprazole formulation with 4week dosing intervals indicated for the treatment of schizophrenia and maintenance monotherapy of bipolar i disorder in adults. See specific package inserts for complete information. Prolixin is used to treat psychotic disorders in adults, such as schizophrenia and delusional disorder. Give sustained release tablets whole need to be swallowed whole. Fluphenazine decanoate is an older, inexpensive lai with considerable interpatient variability in absorption rate and peak effects, and a relatively short duration of action. The prolixin decanoate fluphenazine decanoate fda package insert doesnt have numbers about how common side effects are. Risks from concomitant use with opioids concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma.
Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. See the fda package insert see pregnancy safe medications. For psychotic patients who have been stabilized on a fixed daily dosage or orally administered prolixin fluphenazine hydrochloride dosage forms, conversion to the longacting injectable prolixin fluphenazine decanoate may be indicated see package insert for prolixin decanoate fluphenazine decanoate injection for conversion information. It is available in sesame oil in sterile form for intramuscular im injection. Elderly patients with dementiarelated psychosis treated with antipsychotic drugs are at an increased risk of death. Each ml of haldol decanoate 50 for im injection contains 50 mg. Saphris 5 mg tablets, black cherry flavor, are round, white to offwhite sublingual tablets, with 5 on one side within a circle. This prevents the actions of dopamine, thereby reducing the hallucinations. It is a highly potent behavior modifier with a markedly extended duration of effect.
Diazepam injection, usp concomitant use of barbiturates. For a list of all side effects that have been reported, ask your doctor or pharmacist for the geodon professional package insert. Sensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by highperformance liquid chromatography with coulometric detection. Administer 21 consecutive days of oral aripiprazole. Forced degradation behaviour of fluphenazine hydrochloride by lc and characterization of its oxidative degradation product by lcmsms. Fluphenazine decanoate injection, usp package insert one can expect a higher incidence with fluphenazine decanoate than with less potent piperazine derivatives or with straightchain phenothiazines such as chlorpromazine. Our products are available from authorized distributors. Increased mortality in elderly patients with dementiarelated psychosis. Conversion from hydrochloride dosage forms to decanoate i. For psychotic patients who have been stabilized on a fixed daily dosage or orally administered prolixin fluphenazine hydrochloride dosage forms, conversion to the longacting injectable prolixin decanoate may be indicated see package insert for prolixin decanoate fluphenazine decanoate injection for conversion information. A comparative trial of haloperidol decanoate and fluphenazine decanoate in chronic schizophrenic patients. Haloperidol injection, usp is available as a sterile parenteral form.
Fluphenazine decanoate injection is not approved for the. Dilute oral concentrate in fruit juice, water, carbonated beverage, milk, soup. Fluphenazine is a phenothiazine with antipsychotic activity. Fluphenazine decanoate api manufacturers suppliers. In case of an overdose, call your doctor or poison control center right away or go to the nearest emergency room. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy e. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients. Prolixin fda prescribing information, side effects and uses. Fluphenazine decanoate injection has not been shown effective in the management of behavioral com. Patients receiving fluphenazine decanoate longacting injection may notice some pain at the site of the injection. Haloperidol is the first of the butyrophenone series of major antipsychotics. Highlights of prescribing information these highlights do not include all the information needed to use vraylar safely and effectively.
A twentyweek doubleblind study was conducted to compare the efficacy and sideeffect profile of haloperidol decanoate and fluphenazine decanoate, both given fourweekly, in fiftyone chronic schizophrenic patients. The ndc code 0143952901 is assigned to fluphenazine decanoate also known as. How is this medicine fluphenazine decanoate injection best taken. Fluphenazine decanoate injection auromedics pharma llc. This emedtv page explains that prolixin is not approved for children and covers offlabel prolixin uses for treating dementia and agitation.
Fluphenazine decanoate timing of administration for people with. Fluphenazine decanoate to 25 mg have no history of fluphenazine decanoate injection. Prolixin decanoate fluphenazine decanoate basics, side. Fluphenazine decanoate or enanthate injections are administered via im or subcutaneous injection only, do not administer intravenously. Dailymed fluphenazine decanoate injection, solution. Capitals indicate lifethreatening, underlines indicate most frequent.
The presence of blood dyscrasia or liver damage precludes the use of fluphenazine decanoate. Fluphenazine decanoate injection, usp is available as a clear, pale. For geriatric patients, the suggested starting dose is 1 to 2. Haloperidol decanoate injection package insert haloperidol decanoate injection for im injection only rx only descpription haloperidol decanoate is the decanoate ester of the butyrophenone, haloperidol. Fluphenazine hydrochloride 1 mg pink, identified 1.
The products dosage form is injection, and is administered via intramuscular. Fluphenazine depot injection solutions must be drawn up using a dry syringe and a needle of at least 21gauge. Taking fluphenazine decanoate injection in the third trimester of pregnancy may lead to uncontrolled muscle movements and withdrawal in the newborn. Supporting documents older than three years hespan 6% hetastarch in 0. After administration, release is delayed or 23 weeks during which. It is used in the treatment of chronic psychoses such as schizophrenia, and appears to be about equal in effectiveness to lowpotency antipsychotics like chlorpromazine.
Pharmacology, adverse reactions, warnings and side effects. Fluphenazine decanoate section after pearls for dosing and use continued fluphenazine 291 pharmacokinetics mean halflife of oral formulation approximately 15 hours mean halflife of intramuscular formulation approximately 6. See full prescribing information for complete boxed warning. Prescribing information prfluphenazine fluphenazine hydrochloride tablets usp 1 mg, 2 mg, and 5 mg therapeutic classification antipsychotic pharmacology phenothiazine derivatives appear to act on the hypothalamus, depressing various components of the. Fluphenazine enanthate and decanoate are given im or sc. Fluphenazine hydrochloride tablets, usp, for oral administration, contain 1 mg, 2. With any given phenothiazine derivative, the incidence and severity of such. When acute symptoms have subsided, 25 mg 1 ml of fluphenazine decanoate injection may be.
Fluphenazine may increase the blood levels of a hormone called prolactin. She is receiving paliperidone palmitate, 234 mg every 4 weeks. Drug information fluphenazine decanoate fluphenazine decanoate install pdr s official, free drug information and comparison app today. It works by changing the actions of chemicals in your brain. Find patient medical information for fluphenazine decanoate bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Fluphenazine side effects, dosage, interactions drugs. Fluphenazine decanoate injection, usp is a sterile injection, available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per ml in a sesame oil vehicle with 1. Intramuscular depot injection fluphenazine decanoate or. Fluphenazine decanoate is dissolved in sesame oil for long duration of action.
Prolixin fluphenazine hydrochloride is also available as an oral solution concentrate and a sterile aqueous solution for intramuscular use. Fluphenazine exerts its actions by blocking postsynaptic dopamine d2 receptors in the limbic, cortical system and basal ganglia. For complete ordering information, please contact your local pharmaceutical distributor. Dosing every 7 days may be necessary to avoid peak plasma level adverse effects or symptom recurrence. Use fluphenazine decanoate injection as ordered by your doctor. Fluphenazine is an antipsychotic medicine in a group of drugs called phenothiazines feenohthyeazeens. Privigen is contraindicated in patients with history of anaphylactic or severe systemic reaction to human immune globulin, in patients with hyperprolinemia, and in igadeficient patients with antibodies to iga and a history of hypersensitivity. Find patient medical information for fluphenazine decanoate injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The chemical designation is 44pchlorophenyl4hydroxypiperidino4fluorobutyrophenone and it has the following structural formula. Fluphenazine decanoate inj prescription and dosage sizes information for physicians and healthcare professionals. Fluphenazine, sold under the brand names prolixin among others, is an antipsychotic medication.
Fluphenazine decanoate injection, usp manufacturer name. Fluphenazine decanoate monograph for professionals. Administration of haloperidol decanoate in sesame oil results in slow and sustained. Fluphenazine decanoate injection is contraindicated in comatose or severely depressed states. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing. Fluphenazine decanoate injection, usp par sterile products. Fluphenazine figure 1 is a typical antipsychotic drug from the phenothiazine group, and was approved by the us food and drug administration. Fluphenazine decanoate injection, usp package insert. Haldol decanoate 50 haloperidol haldol decanoate 100.
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